Scott Pilgrim vs. the World: The Game
Partially based on the Oni Press comic book series, Scott Pilgrim vs. the World: The Game is also partially based on the movie, which it shares a title with. With pixel art from the legendary Paul Robertson, no other video game looks like this. At least no other mass-market video game does, especially one published by Ubisoft. A beat em up explicitly inspired by River City Ransom, up to four players could run around beating up baddies, leveling up their stats in shops, and of course fighting ridiculous boss battles against Ramona's evil exes.