Anime Isn't Cool
I mean, I think anime is cool, and a ton of other people do as well. But most people walking into GameStop or whatever don't. "Anime" doesn't actually mean anything, but it has come to sort of represent a certain style that is very much dominant in Japan. And it's a distinct and insular enough style to put people off if they aren't already drinking the Kool-Aid. That's why games more about grit and/or photorealism dominate the AAA scene.