Eggman (Sonic Unleashed)
By the time Sonic Unleashed was, you know, unleashed upon its fanbase, Dr. Eggman had experienced several butt-kickings from the Blue Blur. So when Eggman learns he can summon some kind of demon-thing from beneath the Earth's crust, of course he jumps at the chance. Except, he seems pretty aware of what he needs to do for that, which includes turning Sonic into a werehog. Presumably this version of Earth still has movies; hasn't Eggman at least seen Wolfman? Having a sick, new bioweapon is great and all, but turning your already powerful foil into a bigger, badder, meaner, stretchier(?) version of himself doesn't seem worth the trade.