Joker (Batman: Arkham City)
Almost as long as there has been a Batman, there has been a Joker. The Yin to Batman’s Yang, The Clown Prince of Crime is the other half of the balance of power in Gotham. As Batman’s archenemy, the Joker has been portrayed across all forms of media, from comics and movies to television and video games.
In Batman: Arkham City, Joker has been sick for some time due to the ridiculous amount of Titan he took at the end of Arkham Asylum. In the game’s final confrontation, he attacks Batman, knocking the cure to the ground and losing it forever. Good job, buddy.